Below we have provided a list of significant changes to the site. We hope this will assist you in keeping up-to-date.
14-August-2017 Notice re change to True North Therapeutics and their drugs added to Home Page
11-July-2017 Ruth Lopez added to CADdys
30-May-17 Jeannette Thele added to CADdys
18-February-17 David Adams added to CADdys
7-November-2016 Carole Myers-Rakes added to CADdys and Stories
8-September-2016 Donna Catroppo removed from CADdys List
8-September-2016 Albert Brooks updated his story of 2015.
9-April-2016 Frances Firman added to CADdys and Stories
2-April-2016 Rosella Guiot added to CADdys and Stories
25-February-2016 Vicki Christiansen added to CADdys and Stories
9-February-2016 Two new Links to Other Sites and Articles added - 2014 and 2015 (both from True North Therapeutics, San Francisco)
4-February-2016 New True North Therapeutics Project - see note on Home Page
7-January-2016 Marty Skeeles added to CADdys
28-December-15 Marilyn Kurnell added to CADdys
28-December-15 Debra Kalmbach Rucker added to CADdys
27-December-15 Sadly, if you haven't been on CADdy Chatter, Cam Stanley Sutton in her 50's and Joe Sergio, 97 died this week.
27-December-15 Eleanor Gordon added to CADdys
20-October-15 Cliff Farrell added to CADdys
29-June-15 Susan Dutton added to CADdys
25-June-15 Graeme Hore has updated his 2007 story.
25-June-15 Øivind Bjørkås has updated his 2013 story.
20-June-15 Michelle Byrne added to CADdys
16-June-15 Evelyn Clintsman added to CADdys
28-May-15 Theresa B. Sanborn added to CADdys
15-Mar-15 John Reed added to CADdys
26-Feb-15 Albert Brooks added to CADdys
12-Jan-15 John Hibberd added to CADdys and Stories
29-Dec-14 Laurie Riffle has updated her story.
19-Nov-14 New Drugs for B-Cell Diseases
THE FOLLOWING IS FOR INFORMATION ONLY!!!
The current trend is away from chemotherapy and towards using monoclonal antibodies to treat Blood Cancers and Autoimmune Diseases. There are several new drugs in the pipelines, some approved already for blood cancers--B-Cell chronic lymphocytic leukmias, lymphomas, myelomas and some are showing promise in clinical trials.
These drugs may have potential application for refractory (relapsed) CAD and other autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
One is oral Imbruvica (ibrutinib) a BTK inhibitor, another is Zydelig (Idelalisib) tablets. Gazyva (obinutuzumab) (GA 101) and Arzerra (ofatumumab) (Hu-Max CD-20) a humanized monoclonal antibody most similar to Rituxan. As with many drugs, these have risks of severe toxicities and are not to be used except in stubborn or more severe cases and as determined by your medical professionals. Some have been tested to be used in combination with chemos and/or Rituxan. Rituxan is still the treatment of choice for CAD in addtion to folic acid and keeping warm.
There's much information for you to learn about the above drugs on the internet.
4-Aug-14 Ron Martin added to CADdys
4-May-14 Mark Libecci added to CADdys
4-May-14 Henriette Klaseboer added to CADdys
4-May-14 Silvia Herreros Pompili added to CADdys
4-May-14 Frances Firmin added to CADdys
8-Apr-14 Kathleen Bentzoni added to CADdys
16-Mar-14 Carole Chilton added to CADdys
9-Feb-14 Recommendations on Australian footwear from Fred have been added to Managing CAD
9-Feb-14 Linda Foster added to CADdys
6-Feb-14 Tina Cleveland added to CADdys
6-Feb-14 Pam Wright added to CAddys
4-Feb-14 Elaine Levy added to CADdys
4-Feb-14 TNT009, a Classical Complement Pathway Specific Inhibitor, Prevents Complement Dependent Hemolysis Induced By Cold Agglutinin Disease Patient Autoantibodies added to Links
30-Jan-14 TNT009, a Classical Complement Pathway Specific Inhibitor, Prevents Complement Dependent Hemolysis Induced By Cold Agglutinin Disease Patient Autoantibodies - added to Links
9-Jan-14 Maureen McDonough Roddy added to CADdys
9-Jan-14 Craig Bruesewitz added to CADdys and Stories
10-Dec-13 David McAdam added to CADdys and Stories
29-Nov-13 Joule Charney added to CADdys
24-Nov-13 Earle Messere added to CADdys
15-Oct-13 Stephanie Koll added to CADdys
25-Sep-13 ----US FDA ISSUES BLACK BOXED WARNING TO RITUXAN AND OFATUMUMAB REGARDING POSSIBLE HEPATITIS B VIRUS REACTIVATION
Our Rituximab Page has a link to the article.
21-Sep-13 Art Brown added to CADdys and Stories
15-Sep-13 Rony Zakheym added to CADdys
10-Sep-13 Barry Bonnell added to CADdys and Stories
3-Aug-13 Eva Lawrence added to CADdys
26-Jul-13 Jeri Mastny added to CADdys and Stories
26-Jul-13 Fred Hartman has updated his story
7-Jul-13 Øivind Bjørkås added to CADdys and Stories
25-Jun-13 On the Home page, there are details on how you can take part in a research study for Cold Agglutinin Disease....Betty Usdan.
22-Jun-13 Marla Vanderlaan added to CADdys and Stories
25-May-13 added to CADdys
15-May-13 JH Mater added to CADdys
15-May-13 Cydney Medford added to CADdys
8-May-13 Carol Severin added to CADdys
16-Apr-13 27-Mar-13 Donald Bowman has updated his story
22-Mar-13 Warning on the use of Procrit, Epogen, and Aranesp added to the Treatment Options page
20-Mar-13 Andrea Tulenko-Catlin added to CADdys
19-Mar-13 Rochelle Buckley has added her Dad, Bob Porter, to CADdys
17-Mar-13 Frank Dinovo added to CADdys
16-Feb-13 Bill Masters added to CADdys
13-Feb-13 Natalie Sinclair added to CADdys
7-Jan-13 Karen S has updated her story
4-Jan-13 Fred Hartman added to CADdys and Stories
30-Nov-12 Doreen Thompson added to CADdys
29-Nov-12 Advice on Inoculations and Vaccinations added to the Managing CAD page
22-Nov-12 Annegret Winsor has expanded her Story
20-Nov-12 Lauretta Kurek added to CADdys and Stories
4-Nov-12 Myron Wellan added to CADdys
20-Sep-12 Handling of Blood Specimens per Dr. Sigbjorn Berentsen added to Managing CAD. This explains the procedures to be followed for CADdy blood tests.
30-Aug-12 Dorothy Ingerson has updated her Story
22-Aug-12 Holly & Laing Stevens added to CADdys
8-Aug-12 Martha B added to CADdys
31-Jul-12 Harry Hogan added to CADdys
29-Jul-12 Karen Sperduti added to CADdys and Stories
22-Jul-12 A tip on Cayenne Pepper capsules added to Managing CAD
22-Jul-12 Maurice Reynolds added to CADdys
17-Jul-12 William (Bill) Pennell added to CADdys
17-Jul-12 Tony Murray-Smith added to CADdys
13-Jul-12 Jackie Blake added to CADdys
4-Jul-12 Julia McAnelly added to CADdys
4-Jul-12 Sylvia Allinger added to CADdys
27-Jun-12 Pam Domian added to CADdys
26-Jun-12 Catherine Tokich added to CADdys
26-Jun-12 George Elenbaas added to CADdys
26-Jun-12 Penny Hayes added to CADdys
26-Jun-12 Julia added to CADdys
19-Jun-12 Kathy Cary added to CADdys
24-Apr-12 Kristie added to CADdys and Stories
11-Apr-12 Rituximab should not be warmed or heated but should be infused at room temperature. For further information, see Rituximab Page.
23-Mar-12 CADdy Chatter is a Facebook group you can join. This has been added to the Home page.
13-Mar-12 Dr Sigbjorn Berentsen has written an article "HOW I MANAGE COLD AGGLUTININ DISEASE" published in the May 2011 issue of British Journal of Haematology. Please see the Links page for details.
13-Mar-12 Update added to Barbara Sparks' story
5-Mar-12 Anne W added to CADdys
1-Mar-12 Warm Heart Surgery for those with Cold Agglutinin Disease added to the Links page.
24-Feb-12 From the children in Mrs Kennedy's Classroom we have two new Links on Blood.
25-Jan-12 Update added to Chris Morgan's story
29-Nov-11 Jena Kerns added to CADdys
8-Nov-11 Beverley Walker added to CADdys and Stories
10-Oct-11 Elsa Woodaman added to CADdys and Stories
7-Oct-11 Jean Eames added to CADdys
27-Sep-11 Our condolences go to Connie Vianese on the loss of husband Joe Vianese, from Orlando.
21-Sep-11 Dee R. added to CADdys
7-Aug-11 Katherine Bass added to CADdys
24-Jul-11 Paul Schindler added to CADdys and Stories
20-Jun-11 Mr Leslie Chrol-Frolowicz added to CAddys
10-Jun-11 We have been advised that Patricia Bradley died of complications, aged 87, on 31 May 2011. She had suffered from CAD for over 20 years. Our deepest sympathy goes to her husband Alan.
15-May-11 Penny James added to CADdys
6-May-11 Laraine Aitken added to CADdys and Stories
4-Apr-11 Darlene Strand added to CADdys and Stories
4-Mar-11 Noel daCosta added to CADdys and Stories
2-Feb-11 Laurie Riffle has changed her email address to Click here to send an email
27-Jan-11 Danielle Edwards added to CADdys and Stories
1-Nov-10 Barb Simon added to CADdys and Stories
18-Oct-10 Øivind Bjørkås added to CADdys
18-Oct-10 Barb Johnson has reverted to her maiden name, Barbara Plavecsky
14-Oct-10 Marta Loppery (Canary Islands) is wanting to correspond with a CADdy who can speak Spanish. Marta is on our CADdys page.
12-Oct-10 Cathy Burgett added to CADdys
26-Sep-10 Roger Hudson added to CADdys
9-Aug-10 Our Links page has been updated to remove outdated links, and add new ones.
9-Aug-10 Keith Woods added to CADdys
4-Aug-10 Published 2010 - Newly completed study by Dr Sigbjorn Berentsen et al from Norway. High response rate and durable remissions following fludarabine and rituximab combination therapy for chronic cold agglutinin disease." This report can be downloaded from our Links page.
Also see our comments on the Treatment Options page
10-Jul-10 Laurie Riffle has added good news to her story
21-Jun-10 Jane Doe added to CADdys and Stories
11-May-10 Dorothy Ingerson added to CADdys and Stories
11-May-10 Patricia Bradley added to CADdys
9-May-10 Marta Loppery added to CADdys and Stories
9-May-10 Betty Usdan has updated her story
8-May-10 Annegret Winsor added to CADdys and Stories
8-May-10 Chris Morgan's story updated
8-May-10 James Rockwell added to CADdys
8-May-10 Evelyn Korkmaz added to CADdys
5-Apr-10 Kevin Sidle has an 8 year old daughter with CAD, and would like to contact anyone else who has a child with CAD. Contact Kevin at Click here to send an email
1-Apr-10 Chris Morgan added to CADdys and Stories
16-Mar-10 Madeline Krenek added to CADdys
18-Feb-10 Dennis Fotopoulos added to CADdys and Stories
11-Feb-10 Judy Filipich added to CADdys and Stories
11-Feb-10 Graeme Hore has added an update to his story
23-Jan-10 Barbara & Jay Jablonski added to CADdys and Stories
11-Jan-10 Joni Gerking added to CADdys
30-Dec-09 Juhi Nelson added to CADdys
22-Dec-09 Donald Bowman added to CADdys and Stories
8-Dec-09 Barbara Sparks added to CADdys and Stories
2-Dec-09 Lesley Clark added to CADdys
20-Nov-09 We've been requested to post the following clinical trial but WE DO NOT ENDORSE THE USE OF THIS DRUG FOR CAD.
For Cold Agglutinin Disease patients in Germany, Dr. Alexander Roth, Dept of Hematology, University Hospital Essen, Germany is planning a clinical trial, (DECADE Trial), starting the beginning of 2010 in centers in Germany using eculizumab for the treatment of CAD. Contact: Click here to send an email
5-Nov-09 Judith Desfosses added to CADdys
14-Sep-09 Joanne Scott added to CADdys
7-Aug-09 Ruth Ann Ryan added to CADdys and Stories
6-Aug-09 Peter DeNardis added to CADdys
4-Aug-09 Lael Van Riper added to CADdys and Stories
24-Jul-09 Some CADdys have Waldenstr?m Macroglobulinemia, a malignant disorder of the blood closely related to Lymphoma, so we have added two valuable links. We have been linked on their sites as well.
Bing Center for Waldenstrom's Research, Dana Farber/Harvard Cancer Center http://www.wmprogram.org/Links/Default.asp
Waldenstrom's Macroglobulinemia http://www.stevenptreon.com/links.htm
27-Jun-09 We have been advised that John Harms has died. His story has an addition.
16-Jun-09 Mary Puckett added to CADdys
31-Mar-09 Menna Edwards added to CADdys
11-Mar-09 Valerie Debaix added to CADdys and Stories
2-Feb-09 Jan Rudsenske added to CADdys
26-Jan-09 Information from a CADdy has been added to the Cold Agglutinin Disease page...it is currently the second to last paragraph.
26-Jan-09 Jose Silva added to CADdys
22-Jan-09 Links to two recent articles have been added to the links page.
Rituximab-How it Works and Why Resistance Occurs New Anti-CD20 Monoclonal Antibodies
15-Jan-09 Hilary G. Derby added to CADdys
1-Jan-09 Judith Hubbard added to Stories & CADdys
18-Dec-08 Mary Stearn added to CADdys
5-Dec-08 Roberta Franklin added to Stories
3-Dec-08 Pamela Bedford added to Stories & CADdys
5-Nov-08 Steve Hearne added to Stories & CADdys
5-Nov-08 Joe Sergio added to Stories & CADdys
29-Oct-08 Roberta Franklin added to Stories & CADdys
10-Oct-08 June Davidson added to CADdys
3-Sep-08 Barbara Southall added to Stories & CADdys
23-Aug-08 Rosa Raveneau added to CADdys
25-Jul-08 Mary Lou Lydecker added to Stories & CADdys
3-Jun-08 Rod Coomer added to Stories & CADdys
3-May-08 Mogamat Cassiem Samaai added to CADdys
20-Apr-08 Carol Vanchina added to CADdys
21-Mar-08 Barbara Johnson added to Stories
11-Mar-08 Roberta Franklin added to CADdys
4-Mar-08 Steve Hearn added to CADdys
28-Feb-08 Heather Orr has updated her Story
12-Feb-08 Inge Andersen added to Stories & CADdys
5-Feb-08 Lauren Kenny added to CADdys
31-Jan-08 Tom Kiedrowski added to CADdys
24-Jan-08 Laurie Riffle updated her story regarding her experience with a supplement
17-Jan-08 Barb Johnson added to CADdys
11-Jan-08 Shari Thomas added to CADdys Gloria Storey added to Stories
7-Jan-08 Cécile POIRRIER-GUILMIN added to Stories and CADdys Rosie Sherman added to CADdys Gim Ho Thio added to CADdys
6-Dec-07 Changes made to Links, Treatment Options, Cold Agglutinin Disease, Managing CAD, and Rituximab pages to bring them up to date with current knowledge.
20-Nov-07 Janice Frishkopf added to Stories & CADdys
31-Oct-07 Eleanor Betz added to Stories & CADdys
23-Oct-07 Two newly published articles on CAD by Norway Researchers:
Primary CAD - an update by Sigbjørn Berentsen, Klaus Beiske, & Geir E, Tjonnfjord
B Lymphocytes as targets .....by Sigbjørn Berentsen, Elling Ulvestad, & Geir E, Tjonnfjord
Go to the Links page to view these reports.
14-Oct-07 Rebekah Marshall added to CADdys
14-Sep-07 Ann Close added to Stories & CADdys
14-Sep-07 Donna Catroppo added to CADdys
29-Aug-07 Nina Tartakoff added to Stories & CADdys
15-Aug-07 Recent Additions page added
- CADdys List
- Cold Agglutinin Disease
- Contact Us
- Editorial Board
- Links to Other Sites and Articles
- Managing CAD
- Medical Terms
- Our Stories
- Recent Changes
- Search Results
- Stories 2007
- Stories 2008
- Stories 2009
- Stories 2010
- Stories 2011
- Stories 2012
- Stories 2013
- Stories 2014
- Stories 2015
- Stories 2016
- Treatment Options