Cold Agglutinin Disease Foundation
The Cold Agglutinin Disease Foundation (CADF) is a 501c(3) non-profit corporation dedicated to
the advancement of knowledge about Cold Agglutinin Disease (CAD) for patients, caregivers
and the medical profession. We are committed to creating a healthier life for the greater CAD community
by filling in the informational gaps that exist both for those diagnosed and for our health care providers;
i.e., primary care physicians, hematologists, nurses, and lab technicians.
Cold Agglutinin Disease is a rare type of autoimmune hemolytic anemia in which the body's immune system mistakenly attacks and destroys its own red blood cells. This causes red blood cells to be prematurely destroyed (hemolysis) leading to anemia and other associated signs and symptoms such as extreme fatigue, muscle weakness, trouble breathing, dizziness, rapid heartbeat and pulse, bluish skin and pain, particularly in areas exposed to the cold. CAD patients are more susceptible to blood clots, strokes, and heart issues than the average person. CAD affects both the liver and kidneys, which are having to filter the dead cells. The average age of onset is 58, though there are cases involving much younger and older people. CAD can be caused by lymphoma and cold or flu viruses, but the cause in some cases is unknown. Acquiring a CAD diagnosis is difficult because the disease is very rare and unknown by many physicians.
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